Clinical outcomes and prognostic factors in bloodstream infections due to extended-spectrum ?-lactamase-producing Enterobacteriaceae among patients with malignancy: a meta-analysis.

ABSTRACT: BACKGROUND:The colonization of Extended-spectrum ?-lactamase-producing Enterobacteriaceae (ESBL-PE) in bloodstream infections (BSIs) has been increased dramatically worldwide, and it was associated with worse clinical outcomes in patients with malignancy. We performed the meta-analysis to investigate the prognosis and risk factors in BSIs caused by ESBL-PE in oncological patients. METHODS:PubMed, EMBASE, and Cochrane Library were searched for related studies. All-cause mortality was considered as the primary outcome. Subgroup analyses, meta-regression analyses, and sensitivity analysis were used to investigate heterogeneity and reliability in results. RESULTS:6,729 patients from 25 studies were eligible. Six studies enrolled oncological patients with BSIs caused by ESBL-PE only, while 19 studies both enrolled ESBL-PE and non-ESBL-PE infections. The results showed that BSIs caused by ESBL-PE in patients with malignancy was associated with higher mortality than non-ESBL-PE infections (RR?=?2.21, 95% CI: 1.60-3.06, P?

SUBMITTER: Jiang AM 

PROVIDER: S-EPMC7685587 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature