Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice.
Ontology highlight
ABSTRACT:
Objective: Here we aim to bridge this divide by using diffusion tensor imaging MRI (DTI), an advanced imaging technique commonly applied in human studies, in a longitudinal exercise study with mice.
Methods: Wild-type mice were exercised using voluntary free-wheel running, and MRI scans were at baseline and after four weeks and nine weeks of running.
Results: Both hippocampal volume and fractional anisotropy, a surrogate for microstructural directionality, significantly increased with exercise. In addition, exercise levels correlated with effect size. Histological analysis showed more PDGFR?+ oligodendrocyte precursor cells in the corpus callosum of running mice.
Conclusions: These results provide compelling in vivo support for the concept that similar adaptive changes occur in the brains of mice and humans in response to exercise.
SUBMITTER: Islam MR
PROVIDER: S-EPMC7685674 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice.
Islam Mohammad R MR Luo Renhao R Valaris Sophia S Haley Erin B EB Takase Hajime H Chen Yinching Iris YI Dickerson Bradford C BC Schon Karin K Arai Ken K Nguyen Christopher T CT Wrann Christiane D CD
Brain plasticity (Amsterdam, Netherlands) 20201001 2
<h4>Background</h4>Despite considerable research on exercise-induced neuroplasticity in the brain, a major ongoing challenge in translating findings from animal studies to humans is that clinical and preclinical settings employ very different techniques.<h4>Objective</h4>Here we aim to bridge this divide by using diffusion tensor imaging MRI (DTI), an advanced imaging technique commonly applied in human studies, in a longitudinal exercise study with mice.<h4>Methods</h4>Wild-type mice were exerc ...[more]
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