Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC7685721 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Lee Jinmin J Lundgren Daniel K DK Mao Xuming X Manfredo-Vieira Silvio S Nunez-Cruz Selene S Williams Erik F EF Assenmacher Charles-Antoine CA Radaelli Enrico E Oh Sangwook S Wang Baomei B Ellebrecht Christoph T CT Fraietta Joseph A JA Milone Michael C MC Payne Aimee S AS
The Journal of clinical investigation 20201201 12
Desmoglein 3 chimeric autoantibody receptor T cells (DSG3-CAART) expressing the pemphigus vulgaris (PV) autoantigen DSG3 fused to CD137-CD3ζ signaling domains, represent a precision cellular immunotherapy approach for antigen-specific B cell depletion. Here, we present definitive preclinical studies enabling a first-in-human trial of DSG3-CAART for mucosal PV. DSG3-CAART specifically lysed human anti-DSG3 B cells from PV patients and demonstrated activity consistent with a threshold dose in vivo ...[more]