Tackling the COVID-19 "cytokine storm" with microRNA mimics directly targeting the 3'UTR of pro-inflammatory mRNAs.
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ABSTRACT:
SUBMITTER: Gasparello J
PROVIDER: S-EPMC7685948 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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Tackling the COVID-19 "cytokine storm" with microRNA mimics directly targeting the 3'UTR of pro-inflammatory mRNAs.
Gasparello Jessica J Finotti Alessia A Gambari Roberto R
Medical hypotheses 20201125
COVID-19 is characterized by two major clinical phases, the SARS-CoV-2 infection of target cells and tissues, and a deep inflammatory state, known as "cytokine storm", caused by activation of pro-inflammatory genes, such as NF-kB, STAT-3, IL-6, IL-8, IL-1ß. Among possible anti-inflammatory agents, the "microRNA targeting" should be carefully considered, since it is well known that microRNAs are deeply involved in the expression of cytokines, chemokines and growth factors. The working general hyp ...[more]
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