Evaluation of IL-17D in Host Immunity to Group A Streptococcus Infection.

ABSTRACT: IL-17D is a cytokine that belongs to the IL-17 family and is conserved in vertebrates and invertebrates. In contrast to IL-17A and IL-17F, which are expressed in Th17 cells, IL-17D is expressed broadly in nonimmune cells. IL-17D can promote immune responses to cancer and viruses in part by inducing chemokines and recruiting innate immune cells such as NK cells. Although bacterial infection can induce IL-17D in fish and invertebrates, the role of mammalian IL-17D in antibacterial immunity has not been established. To determine whether IL-17D has a role in mediating host defense against bacterial infections, we studied i.p. infection by group A Streptococcus (GAS) in wild-type (WT) and Il17d ^-/- mice. Compared with WT animals, mice deficient in IL-17D experienced dec

SUBMITTER: Washington A 

PROVIDER: S-EPMC7686091 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature