Ontology highlight
ABSTRACT:
SUBMITTER: Ben Baruch B
PROVIDER: S-EPMC7686132 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Laboratory investigation; a journal of technical methods and pathology 20200701 12
Primary and metastatic melanoma progression are supported by a local microenvironment comprising, inter alia, of cancer-associated fibroblasts (CAFs). We previously reported in orthotropic/syngeneic mouse models that the stromal ectoenzyme CD38 participates in melanoma growth and metastasis. The results presented here suggest that CD38 is a novel regulator of CAFs' pro-tumorigenic functions. Orthotopic co-implantation of CD38 deficient fibroblasts and B16F10 melanoma cells limited tumor size, co ...[more]