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Influencing factors of cardiorespiratory fitness in allogeneic stem cell transplant candidates prior to transplantation.

ABSTRACT: PURPOSE:Cardiorespiratory fitness (CRF) seems to be prognostic prior to allogeneic stem cell transplantation (allo-HSCT). Influencing factors of CRF in allo-HSCT candidates have not been studied so far. Aim was to identify potentially influencing factors on CRF. METHODS:To assess CRF, a maximal cardiopulmonary exercise test (CPET) was performed on average 2.6?±?7.2 days prior to admission. A regression analysis was conducted, with the following predictors: gender, age, body mass index (BMI), time between last therapy and allo-HSCT (t_Therapies), number of cardiotoxic therapies (n_Cardiotox), number of transplantations (n_Transplantations), comorbidity index (HCT-CI), hemoglobin level of the last 3 months (area under the curve), and physical activity. RESULTS:A total of 194 patients performed a CPET. VO2peak was significantly reduced compared with reference data. In total, VO2peak was 21.4 ml/min/kg (-?27.5%, p?2peak was significantly (p?

SUBMITTER: Limbach M 

PROVIDER: S-EPMC7686174 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Influencing factors of cardiorespiratory fitness in allogeneic stem cell transplant candidates prior to transplantation.

Limbach Matthias M   Kuehl Rea R   Dreger Peter P   Luft Thomas T   Rosenberger Friederike F   Kleindienst Nikolaus N   Friedmann-Bette Birgit B   Bondong Andrea A   Bohus Martin M   Wiskemann Joachim J  

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20200504 1

<h4>Purpose</h4>Cardiorespiratory fitness (CRF) seems to be prognostic prior to allogeneic stem cell transplantation (allo-HSCT). Influencing factors of CRF in allo-HSCT candidates have not been studied so far. Aim was to identify potentially influencing factors on CRF.<h4>Methods</h4>To assess CRF, a maximal cardiopulmonary exercise test (CPET) was performed on average 2.6 ± 7.2 days prior to admission. A regression analysis was conducted, with the following predictors: gender, age, body mass i  ...[more]

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