Ontology highlight
ABSTRACT:
SUBMITTER: Jeon YM
PROVIDER: S-EPMC7686475 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Jeon Yu-Mi YM Kwon Younghwi Y Jo Myungjin M Lee Shinrye S Kim Seyeon S Kim Hyung-Jun HJ
Frontiers in cell and developmental biology 20201111
The abnormal accumulation of alpha-synuclein (α-syn) aggregates in neurons and glial cells is widely known to be associated with many neurodegenerative diseases, including Parkinson's disease (PD), Dementia with Lewy bodies (DLB), and Multiple system atrophy (MSA). Mitochondrial dysfunction in neurons and glia is known as a key feature of α-syn toxicity. Studies aimed at understanding α-syn-induced toxicity and its role in neurodegenerative diseases have primarily focused on neurons. However, a ...[more]