Ontology highlight
ABSTRACT:
SUBMITTER: Smith AK
PROVIDER: S-EPMC7686485 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Nature communications 20201124 1
Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed controls. Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date. Ten cohorts, military and civilian, contribute blood-derived DNA methylation data from 1,896 PTSD cases and trauma-exposed controls. Four CpG sites within the aryl-hydrocarbon receptor repressor (AHRR) associate with PTSD after adjustment for multiple comparisons, with lower DNA methylation in PTSD cases relativ ...[more]