HIF-1? Directly Controls WNT7A Expression During Myogenesis.
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ABSTRACT:
SUBMITTER: Cirillo F
PROVIDER: S-EPMC7686515 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
HIF-1α Directly Controls WNT7A Expression During Myogenesis.
Cirillo Federica F Resmini Giulia G Angelino Elia E Ferrara Michele M Tarantino Adriana A Piccoli Marco M Rota Paola P Ghiroldi Andrea A Monasky Michelle M MM Ciconte Giuseppe G Pappone Carlo C Graziani Andrea A Anastasia Luigi L
Frontiers in cell and developmental biology 20201111
Herein we unveil that Hypoxia-inducible factor-1α (HIF-1α) directly regulates <i>WNT7A</i> expression during myogenesis. In fact, chromatin immunoprecipitation (ChiP) and site-directed mutagenesis experiments revealed two distinct hypoxia response elements (HREs) that are specific HIF-1α binding sites on the <i>WNT7A</i> promoter. Remarkably, a pharmacological activation of HIF-1α induced <i>WNT7A</i> expression and enhanced muscle differentiation. On the other hand, silencing of <i>WNT7A</i> us ...[more]
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