Ontology highlight
ABSTRACT:
SUBMITTER: Kawamura A
PROVIDER: S-EPMC7686671 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Kawamura Atsuki A Abe Yoshifumi Y Seki Fumiko F Katayama Yuta Y Nishiyama Masaaki M Takata Norio N Tanaka Kenji F KF Okano Hideyuki H Nakayama Keiichi I KI
Molecular brain 20201123 1
CHD8 encodes a chromatin-remodeling factor and is one of the most recurrently mutated genes in individuals with autism spectrum disorder (ASD). Although we have recently shown that mice heterozygous for Chd8 mutation manifest myelination defects and ASD-like behaviors, the detailed mechanisms underlying ASD pathogenesis have remained unclear. Here we performed diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rsfMRI) in oligodendrocyte lineage-specific Chd8 ...[more]