Ontology highlight
ABSTRACT:
SUBMITTER: Koopman I
PROVIDER: S-EPMC7687754 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Trials 20201125 1
<h4>Background</h4>The inflammatory response after aneurysmal subarachnoid haemorrhage (aSAH) has been associated with early brain injury, delayed cerebral ischaemia, poor functional outcome, and case fatality. In experimental SAH studies, complement C5 antibodies administered shortly after SAH reduced brain injury with approximately 40%. Complement component C5 may be a new therapeutic target to reduce brain injury and hereby improve the outcome after aSAH. We aim to investigate the pharmacodyn ...[more]