Vascular endothelial growth factor promotes atrial arrhythmias by inducing acute intercalated disk remodeling.
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ABSTRACT:
SUBMITTER: Mezache L
PROVIDER: S-EPMC7687901 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Vascular endothelial growth factor promotes atrial arrhythmias by inducing acute intercalated disk remodeling.
Mezache Louisa L Struckman Heather L HL Greer-Short Amara A Baine Stephen S Györke Sándor S Radwański Przemysław B PB Hund Thomas J TJ Veeraraghavan Rengasayee R
Scientific reports 20201124 1
Atrial fibrillation (AF) is the most common arrhythmia and is associated with inflammation. AF patients have elevated levels of inflammatory cytokines known to promote vascular leak, such as vascular endothelial growth factor A (VEGF). However, the contribution of vascular leak and consequent cardiac edema to the genesis of atrial arrhythmias remains unknown. Previous work suggests that interstitial edema in the heart can acutely promote ventricular arrhythmias by disrupting ventricular myocyte ...[more]
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