Ontology highlight
ABSTRACT:
SUBMITTER: Lucas ED
PROVIDER: S-EPMC7688291 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Cell reports 20201001 2
Although the function of the extracellular region of programmed death ligand 1 (PD-L1) through its interactions with PD-1 on T cells is well studied, little is understood regarding the intracellular domain of PD-L1. Here, we outline a major role for PD-L1 intracellular signaling in the control of dendritic cell (DC) migration from the skin to the draining lymph node (dLN). Using a mutant mouse model, we identify a TSS signaling motif within the intracellular domain of PD-L1. The TSS motif proves ...[more]