Ontology highlight
ABSTRACT:
SUBMITTER: Hamadani CM
PROVIDER: S-EPMC7688330 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Hamadani Christine M CM Goetz Morgan J MJ Mitragotri Samir S Tanner Eden E L EEL
Science advances 20201125 48
The rapid clearance of intravenously administered nanoparticles (NPs) from the bloodstream is a major unsolved problem in nanomedicine. Here, we describe the first use of biocompatible protein-avoidant ionic liquids (PAILs) as NP surface modifiers to reduce opsonization. An ionic liquid choline hexenoate, selected for its aversion to serum proteins, was used to stably coat the surface of poly(lactic-<i>co</i>-glycolic acid) (PLGA) NPs. Compared with bare PLGA and poly(ethylene glycol)-coated PLG ...[more]