Ontology highlight
ABSTRACT:
SUBMITTER: Zhou F
PROVIDER: S-EPMC7688343 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Zhou Fuchun F Elzi David J DJ Jayabal Panneerselvam P Ma Xiuye X Chiu Yu-Chiao YC Chen Yidong Y Blackman Barron B Weintraub Susan T ST Houghton Peter J PJ Shiio Yuzuru Y
Cell reports 20201101 5
We report here that the autocrine signaling mediated by growth and differentiation factor 6 (GDF6), a member of the bone morphogenetic protein (BMP) family of cytokines, maintains Ewing sarcoma growth by preventing Src hyperactivation. Surprisingly, Ewing sarcoma depends on the prodomain, not the BMP domain, of GDF6. We demonstrate that the GDF6 prodomain is a ligand for CD99, a transmembrane protein that has been widely used as a marker of Ewing sarcoma. The binding of the GDF6 prodomain to the ...[more]