Ontology highlight
ABSTRACT:
SUBMITTER: Veazey KJ
PROVIDER: S-EPMC7688486 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Leukemia 20200624 12
Somatic mutations affecting CREBBP and EP300 are a hallmark of diffuse large B-cell lymphoma (DLBCL). These mutations are frequently monoallelic, within the histone acetyltransferase (HAT) domain and usually mutually exclusive, suggesting that they might affect a common pathway, and their residual WT expression is required for cell survival. Using in vitro and in vivo models, we found that inhibition of CARM1 activity (CARM1i) slows DLBCL growth, and that the levels of sensitivity are positively ...[more]