An epigenome-wide association study of metabolic syndrome and its components.

ABSTRACT: The role of metabolic syndrome (MetS) as a preceding metabolic state for type 2 diabetes and cardiovascular disease is widely recognised. To accumulate knowledge of the pathological mechanisms behind the condition at the methylation level, we conducted an epigenome-wide association study (EWAS) of MetS and its components, testing 1187 individuals of European ancestry for approximately 470 000 methylation sites throughout the genome. Methylation site cg19693031 in gene TXNIP -previously associated with type 2 diabetes, glucose and lipid metabolism, associated with fasting glucose level (P?=?1.80?×?10-8). Cg06500161 in gene ABCG1 associated both with serum triglycerides (P?=?5.36?×?10-9) and waist circumference (P?=?5.21?×?10-9). The previously identified type 2 diabetes-associated locus cg08309687 in chromosome 21 associated with waist circumference for the first time (P?=?2.24?×?10-7). Furthermore, a novel HDL association with cg17901584 in chromosome 1 was identified (P?=?7.81?×?10-8). Our study supports previous genetic studies of MetS, finding that lipid metabolism plays a key role in pathology of the syndrome. We provide evidence regarding a close interplay with glucose metabolism. Finally, we suggest that in attempts to identify methylation loci linking separate MetS components, cg19693031 appears to represent a strong candidate.

SUBMITTER: Nuotio ML 

PROVIDER: S-EPMC7688654 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature