Ontology highlight
ABSTRACT:
SUBMITTER: Luo T
PROVIDER: S-EPMC7689030 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Luo Tao T Liu Qiaoyuan Q Tan Aihua A Duan Lixia L Jia Yuxian Y Nong Li L Tang Jing J Zhou Wenxian W Xie Weimin W Lu Yongkui Y Yu Qiang Q Yu Qiang Q Liu Yan Y
Molecular therapy oncolytics 20201020
Emerging evidence has shown the role of mesenchymal stem cell-derived exosome (MSC-exo) in inducing resistance of cancer cells to chemotherapy. However, it remains unclear whether the change of MSC-exo in response to chemotherapy also contributes to chemoresistance. In this study, we investigated the effect of a standard-of-care chemotherapeutic agent, doxorubicin (Dox), on MSC-exo and its contribution to the development of Dox resistance in breast cancer cells (BCs). We found that the exosome s ...[more]