Ontology highlight
ABSTRACT:
SUBMITTER: Ledet MM
PROVIDER: S-EPMC7689471 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Ledet Melissa M MM Harman Rebecca M RM Fan Jennifer C JC Schmitt-Matzen Emily E Diaz-Rubio Maria Elena ME Zhang Sheng S Van de Walle Gerlinde R GR
Scientific reports 20201125 1
Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is present in domesticated mammals with a low mammary cancer incidence. Specifically, these bioactive factors induced triple-negative breast cancer cell (TNBC) death in vitro and reduced tumorigenicity in a xenograft TNBC mouse model in vivo. RNA deep seq ...[more]