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A meta-analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale.


ABSTRACT: Certain population groups are known to have higher than average anal cancer risk, namely persons living with HIV (PLHIV), men who have sex with men (MSM), women diagnosed with human papillomavirus (HPV)-related gynecological precancerous lesions or cancer, solid organ transplant recipients (SOTRs) and patients with autoimmune diseases. Our aim was to provide robust and comparable estimates of anal cancer burden across these groups. Summary incidence rates (IRs), as cases per 100?000 person-years (py), were calculated by fixed-effects meta-analysis. IRs were 85 (95% confidence interval [CI] = 82-89) for HIV-positive MSM (n = 7 studies; 2 229?234?py), 32 (95% CI = 30-35) for non-MSM male PLHIV (n = 5; 1626?448?py) and 22 (95% CI = 19-24) for female PLHIV (n = 6; 1 472?123?py), with strong variation by age (eg, from 16.8?10?years after transplant. Anal cancer IRs were 10 (95% CI = 5-19), 6 (95% CI = 3-11) and 3 (95% CI = 2-4) for systemic lupus erythematosus, ulcerative colitis and Crohn's disease, respectively. In conclusion, a unifying anal cancer risk scale, based upon comprehensive meta-analysis, can improve prioritization and standardization in anal cancer prevention/research initiatives, which are in their public health infancy.

SUBMITTER: Clifford GM 

PROVIDER: S-EPMC7689909 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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A meta-analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale.

Clifford Gary M GM   Georges Damien D   Shiels Meredith S MS   Engels Eric A EA   Albuquerque Andreia A   Poynten Isobel Mary IM   de Pokomandy Alexandra A   Easson Alexandra M AM   Stier Elizabeth A EA  

International journal of cancer 20200729 1


Certain population groups are known to have higher than average anal cancer risk, namely persons living with HIV (PLHIV), men who have sex with men (MSM), women diagnosed with human papillomavirus (HPV)-related gynecological precancerous lesions or cancer, solid organ transplant recipients (SOTRs) and patients with autoimmune diseases. Our aim was to provide robust and comparable estimates of anal cancer burden across these groups. Summary incidence rates (IRs), as cases per 100 000 person-years  ...[more]

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