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A meta-analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale.

ABSTRACT: Certain population groups are known to have higher than average anal cancer risk, namely persons living with HIV (PLHIV), men who have sex with men (MSM), women diagnosed with human papillomavirus (HPV)-related gynecological precancerous lesions or cancer, solid organ transplant recipients (SOTRs) and patients with autoimmune diseases. Our aim was to provide robust and comparable estimates of anal cancer burden across these groups. Summary incidence rates (IRs), as cases per 100?000 person-years (py), were calculated by fixed-effects meta-analysis. IRs were 85 (95% confidence interval [CI] = 82-89) for HIV-positive MSM (n = 7 studies; 2 229?234?py), 32 (95% CI = 30-35) for non-MSM male PLHIV (n = 5; 1626?448?py) and 22 (95% CI = 19-24) for female PLHIV (n = 6; 1 472?123?py), with strong variation by age (eg, from 16.8?10?years after transplant. Anal cancer IRs were 10 (95% CI = 5-19), 6 (95% CI = 3-11) and 3 (95% CI = 2-4) for systemic lupus erythematosus, ulcerative colitis and Crohn's disease, respectively. In conclusion, a unifying anal cancer risk scale, based upon comprehensive meta-analysis, can improve prioritization and standardization in anal cancer prevention/research initiatives, which are in their public health infancy.

SUBMITTER: Clifford GM

PROVIDER: S-EPMC7689909 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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A meta-analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale.

Clifford Gary M GM Georges Damien D Shiels Meredith S MS Engels Eric A EA Albuquerque Andreia A Poynten Isobel Mary IM de Pokomandy Alexandra A Easson Alexandra M AM Stier Elizabeth A EA

International journal of cancer 20200729 1

Certain population groups are known to have higher than average anal cancer risk, namely persons living with HIV (PLHIV), men who have sex with men (MSM), women diagnosed with human papillomavirus (HPV)-related gynecological precancerous lesions or cancer, solid organ transplant recipients (SOTRs) and patients with autoimmune diseases. Our aim was to provide robust and comparable estimates of anal cancer burden across these groups. Summary incidence rates (IRs), as cases per 100 000 person-years ...[more]

PMID: 32621759

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Project description:ImportancePatients with schizophrenia are considered to have many risk factors for the development of cancer. However, the incidence of breast cancer in women with schizophrenia compared with the general population remains uncertain.ObjectiveTo perform an updated meta-analysis to evaluate the association between schizophrenia and the risk of breast cancer.Data sourcesA systematic search of the PubMed and EMBASE databases was conducted using the search terms schizophrenia, schizophrenic, psychosis, combined with breast and cancer, tumor, neoplasm, or carcinoma. The final literature search was performed on August 15, 2017.Study selectionCohort studies reporting the standardized incidence ratio (SIR) for the risk of breast cancer in women with schizophrenia compared with the general population.Data extraction and synthesisThe meta-analysis adhered to Meta-analysis of Observational Studies in Epidemiology and the Cochrane Handbook for Systematic Reviews of Interventions. Data extraction was performed independently. A random-effects model was used to pool the results, and a recently proposed prediction interval was calculated to describe the heterogeneity.Main outcomes and measuresThe SIR for the risk of breast cancer in women with schizophrenia compared with the general population or those without schizophrenia.ResultsTwelve cohorts including 125?760 women were included in this meta-analysis. The results of the meta-analysis showed that schizophrenia was associated with a significantly increased risk of breast cancer incidence in women (SIR, 1.31; 95% CI, 1.14-1.50; P?<?.001), with significant heterogeneity (P?<?.001; I2?=?89%). Substantial between-study variance was also suggested by the wide prediction interval (0.81-2.10), which indicated that it is possible that a future study will show a decreased breast cancer risk in women with schizophrenia compared with the general population. The subgroup analysis results showed that the association was not significantly affected by whether breast cancer cases were excluded at baseline or the sample size of the included studies.Conclusions and relevanceThe incidence of breast cancer in women with schizophrenia is higher than that of the general female population. However, significant heterogeneity exists among the included studies. Women with schizophrenia deserve intensive prevention and treatment of breast cancer.

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Dataset Information

A meta-analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale.

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A meta-analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale.

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