Ontology highlight
ABSTRACT:
SUBMITTER: do Canto LM
PROVIDER: S-EPMC7690383 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
do Canto Luisa Matos LM Barros-Filho Mateus Camargo MC Rainho Cláudia Aparecida CA Marinho Diogo D Kupper Bruna Elisa Catin BEC Begnami Maria Dirlei Ferreira de Souza MDFS Scapulatempo-Neto Cristovam C Havelund Birgitte Mayland BM Lindebjerg Jan J Marchi Fabio Albuquerque FA Baumbach Jan J Aguiar Samuel S Rogatto Silvia Regina SR
Cancers 20201022 11
The treatment for locally advanced rectal carcinomas (LARC) is based on neoadjuvant chemoradiotherapy (nCRT) and surgery, which results in pathological complete response (pCR) in up to 30% of patients. Since epigenetic changes may influence response to therapy, we aimed to identify DNA methylation markers predictive of pCR in LARC patients treated with nCRT. We used high-throughput DNA methylation analysis of 32 treatment-naïve LARC biopsies and five normal rectal tissues to explore the predicti ...[more]