Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment?
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ABSTRACT:
SUBMITTER: Cosin-Roger J
PROVIDER: S-EPMC7690732 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment?
Cosín-Roger Jesús J Ortiz-Masia Dolores D Barrachina Maria Dolores MD Calatayud Sara S
Cells 20201023 11
G-protein-coupled receptors constitute the most diverse and largest receptor family in the human genome, with approximately 800 different members identified. Given the well-known metabolic alterations in cancer development, we will focus specifically in the 19 G-protein-coupled receptors (GPCRs), which can be selectively activated by metabolites. These metabolite sensing GPCRs control crucial processes, such as cell proliferation, differentiation, migration, and survival after their activation. ...[more]
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