Plant-Derived Natural Compounds in Genetic Vaccination and Therapy for HPV-Associated Cancers.

ABSTRACT: Antigen-specific immunotherapy and, in particular, DNA vaccination provides an established approach for tackling human papillomavirus (HPV) cancers at different stages. DNA vaccines are stable and have a cost-effective production. Their intrinsic low immunogenicity has been improved by several strategies with some success, including fusion of HPV antigens with plant gene sequences. Another approach for the control of HPV cancers is the use of natural immunomodulatory agents like those derived from plants, that are able to interfere in carcinogenesis by modulating many different cellular pathways and, in some instances, to reduce chemo- and radiotherapy resistance of tumors. Indeed, plant-derived compounds represent, in many cases, an abundantly available, cost-effective source of molecules

SUBMITTER: Franconi R 

PROVIDER: S-EPMC7690868 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature