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Pollens derived magnetic porous particles for adsorption of low-density lipoprotein from plasma.


ABSTRACT: Adsorption of low-density lipoprotein from plasma is vital for the treatment of dyslipidemia. Appropriate adsorbent material for efficient and selective adsorption of low-density lipoprotein is highly desired. In this work, we developed pollens-derived magnetic porous particles as adsorbents for this purpose. The natural pollen grains were modified to obtain high surface porosity, a large inner cavity, magnet responsiveness, and specific wettability. The resultant particles exhibited satisfying performance in the adsorption of a series of oils and organic solvents out of water. Besides, the particles were directly utilized to the adsorption of low-density lipoprotein in plasma, which showed high selectivity, and achieved an outstanding adsorption capacity as high as 34.9% within 2 h. Moreover, their salient biocompatibility was demonstrated through simulative hemoperfusion experiments. These features, together with its abundant source and facile fabrication, makes the pollens-derived magnetic porous particles excellent candidate for low-density lipoprotein -apheresis and water treatment applications.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7691160 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Pollens derived magnetic porous particles for adsorption of low-density lipoprotein from plasma.

Wang Yuetong Y   Sun Lingyu L   Guo Jiahui J   Shi Keqing K   Shang Luoran L   Xiao Jian J   Zhao Yuanjin Y  

Bioactive materials 20201120 6


Adsorption of low-density lipoprotein from plasma is vital for the treatment of dyslipidemia. Appropriate adsorbent material for efficient and selective adsorption of low-density lipoprotein is highly desired. In this work, we developed pollens-derived magnetic porous particles as adsorbents for this purpose. The natural pollen grains were modified to obtain high surface porosity, a large inner cavity, magnet responsiveness, and specific wettability. The resultant particles exhibited satisfying  ...[more]

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