Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy.
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ABSTRACT:
SUBMITTER: Hoh RA
PROVIDER: S-EPMC7691169 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Origins and clonal convergence of gastrointestinal IgE<sup>+</sup> B cells in human peanut allergy.
Hoh Ramona A RA Joshi Shilpa A SA Lee Ji-Yeun JY Martin Brock A BA Varma Sushama S Kwok Shirley S Nielsen Sandra C A SCA Nejad Parastu P Haraguchi Emily E Dixit Priya S PS Shutthanandan Swetha V SV Roskin Krishna M KM Zhang Wenming W Tupa Dana D Bunning Bryan J BJ Manohar Monali M Tibshirani Robert R Fernandez-Becker Nielsen Q NQ Kambham Neeraja N West Robert B RB Hamilton Robert G RG Tsai Mindy M Galli Stephen J SJ Chinthrajah Rebecca S RS Nadeau Kari C KC Boyd Scott D SD
Science immunology 20200301 45
B cells in human food allergy have been studied predominantly in the blood. Little is known about IgE<sup>+</sup> B cells or plasma cells in tissues exposed to dietary antigens. We characterized IgE<sup>+</sup> clones in blood, stomach, duodenum, and esophagus of 19 peanut-allergic patients, using high-throughput DNA sequencing. IgE<sup>+</sup> cells in allergic patients are enriched in stomach and duodenum, and have a plasma cell phenotype. Clonally related IgE<sup>+</sup> and non-IgE-expressin ...[more]
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