Ontology highlight
ABSTRACT:
SUBMITTER: Zhang JM
PROVIDER: S-EPMC7691497 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Zhang Jia-Ming JM Hou Wei-Bo WB Du Jia-Wei JW Zong Ming M Zheng Kai-Lun KL Wang Wei-Jia WJ Wang Jia-Qiang JQ Zhang Heng H Mu Yan-Shuang YS Yin Zhi Z Ding Chun-Ming CM Sun Qing-Yuan QY Liu Zhong-Hua ZH Kong Qing-Ran QR
Cell death discovery 20201127 1
In mammalian early embryos, the transition from maternal to embryonic control of gene expression requires timely degradation of a subset of maternal mRNAs (MRD). Recently, zygotic genome activation (ZGA)-dependent MRD has been characterized in mouse 2-cell embryo. However, in early embryos, the dynamics of MRD is still poorly understood, and the maternal factor-mediated MRD before and along with ZGA has not been investigated. Argonaute 2 (Ago2) is highly expressed in mouse oocyte and early embry ...[more]