Dataset Information

Development and validation of Hyperacusis Handicap Questionnaire in individuals with tinnitus associated with hyperacusis.

ABSTRACT: Introduction: Hypersensitivity to sound and tinnitus are often co-morbid and can influence emotional well-being, hearing, sleep, concentration, cause anxiety, and interfere with speech perception in noise.

Purpose: A clear measure of sensitivity to sound is important as there is dearth in standard protocol for evaluating hyperacusis in individuals with tinnitus. Although there are a few questionnaires to assess hyperacusis, a direct application of these questionnaires in the Indian context would be unfavorable.

Objectives: The study attempts to develop and validate an indigenous Hyperacusis Handicap Questionnaire (HHQ) for individuals with tinnitus associated with hyperacusis.

Method: A total of 25 questions were considered for validation. Further, 21 questions were subdivided into three sections of seven questions each, tapping, 'Functional,' 'Social,' and 'Emotional' aspects of the condition. It was administered on 77 individuals with tinnitus associated with hyperacusis in the age range of 20-55 years for further validation. A total score was obtained by adding all the three sub-scales.

Results: The internal consistency of the questionnaire was determined by Cronbach's Alpha (?) was ? = 0.85; and, ? = 0.83 for Functional, ? = 0.81 for Social, ? = 0.7 for Emotional subscales suggesting that the questionnaire can be used for the assessment of handicap associated with hyperacusis in individuals with tinnitus. Also, no significant difference in terms of gender and duration of tinnitus comparisons were seen.

Conclusions: The obtained results suggest that HHQ will aid in the characterization and quantification of the handicap associated with hyperacusis in individuals with tinnitus.

SUBMITTER: Prabhu P

PROVIDER: S-EPMC7691828 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Publications

Development and validation of Hyperacusis Handicap Questionnaire in individuals with tinnitus associated with hyperacusis.

Prabhu Prashanth P Nagaraj Megha Kondli MK

Journal of otology 20200102 4

<h4>Introduction</h4>Hypersensitivity to sound and tinnitus are often co-morbid and can influence emotional well-being, hearing, sleep, concentration, cause anxiety, and interfere with speech perception in noise.<h4>Purpose</h4>A clear measure of sensitivity to sound is important as there is dearth in standard protocol for evaluating hyperacusis in individuals with tinnitus. Although there are a few questionnaires to assess hyperacusis, a direct application of these questionnaires in the Indian ...[more]

PMID: 33293911

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Project description:Objective: The need for validated measures enabling clinicians to classify tinnitus patients according to the severity of tinnitus and screen the progress of therapies in our country led us to translate into Polish and to validate two tinnitus questionnaires, namely the Tinnitus Handicap Inventory (THI) and the Tinnitus Functional Index (TFI). Design: The original English versions of the questionnaires were translated into Polish and translated back to English by three independent translators. These versions were then finalized by the authors into a Polish THI (THI-Pl) and a Polish TFI (TFI-Pl). Participants from three laryngological centers in Poland anonymously answered the THI-Pl (N = 98) and the TFI-Pl (N = 108) in addition to the Polish versions of the Center for Epidemiologic Studies Depression Scale as a measure of self-perceived level of depression, and the Satisfaction With Life Scale to assess self-perceived quality of life. Both were used to determine discriminant validity. Two Visual Analog Scales were used to measure tinnitus annoyance and tinnitus loudness in order to determine convergent validity. Results: Similar to the original version of the THI, the THI-Pl showed a high internal consistency (Cronbach's α = 0.93). The exploratory factor analysis revealed that the questionnaire has a three-factorial structure that does not correspond to the original division for functional, catastrophic, and emotional subscales. Convergent and discriminant validities were confirmed. The TFI-Pl showed high internal consistency (Cronbach's α = 0.96) with the reliability ranging from 0.82 to 0.95 for its different subscales. Factor analysis confirmed an eight-factorial structure with factors assigning all items to appropriate subscales reported in the original version of the questionnaire. Discriminant and convergent validities were also confirmed for the TFI-Pl. Conclusion: We translated and validated the Polish versions of the THI and the TFI to make them suitable for clinical use in Poland.

Project description:Aminoglycosides (AG) antibiotics are a common treatment for recurrent infections in cystic fibrosis (CF) patients. AGs are highly ototoxic, resulting in a range of auditory dysfunctions. It was recently shown that the acoustic startle reflex (ASR) can assess behavioral evidence of hyperacusis and tinnitus in an amikacin cochleotoxicity mouse model. The goal of this study was to establish if tobramycin treatment led to similar changes in ASR behavior and to establish whether ebselen can prevent the development of these maladaptive neuroplastic symptoms. CBA/Ca mice were divided into three groups: Group 1 served as a control and did not receive tobramycin or ebselen, Group 2 received tobramycin (200 mg/kg/s.c.) and the vehicle (DMSO/saline/i.p.) daily for 14 continuous days, and Group 3 received the same dose/schedule of tobramycin as Group 2 and ebselen at (20 mg/kg/i.p.). Auditory brainstem response (ABR) and ASR hearing assessments were collected at baseline and 2, 6, 10, 14, and 18 weeks from the start of treatment. ASR tests included input/output (I/O) functions which assess general hearing and hyperacusis, and Gap-induced prepulse inhibition of the acoustic startle (GPIAS) to assess tinnitus. At 18 weeks, histologic analysis showed predominantly normal appearing hair cells and spiral ganglion neuron (SGN) synapses. Following 14 days of tobramycin injections, 16 kHz thresholds increased from baseline and fluctuated over the 18-week recovery period. I/O functions revealed exaggerated startle response magnitudes in 50% of mice over the same period. Gap detection deficits, representing behavioral evidence of tinnitus, were observed in a smaller subset (36%) of animals. Interestingly, increases in ABR wave III/wave I amplitude ratios were observed. These tobramycin data corroborate previous findings that AGs can result in hearing dysfunctions. We show that a 14-day course of tobramycin treatment can cause similar levels of hearing loss and tinnitus, when compared to a 14-day course of amikacin, but less hyperacusis. Evidence suggests that tinnitus and hyperacusis might be common side effects of AG antibiotics.

Dataset Information

Development and validation of Hyperacusis Handicap Questionnaire in individuals with tinnitus associated with hyperacusis.

Publications

Development and validation of Hyperacusis Handicap Questionnaire in individuals with tinnitus associated with hyperacusis.

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