Dataset Information

Poly(N,N'-Diethylacrylamide)-Based Thermoresponsive Hydrogels with Double Network Structure.

ABSTRACT: Temperature response of double network (DN) hydrogels composed of thermoresponsive poly(N,N'-diethylacrylamide) (PDEAAm) and hydrophilic polyacrylamide (PAAm) or poly(N,N`-dimethylacrylamide) (PDMAAm) was studied by a combination of swelling measurements, differential scanning calorimetry (DSC) and 1H NMR and UV-Vis spectroscopies. Presence of the second hydrophilic network in DN hydrogels influenced their thermal sensitivity significantly. DN hydrogels show less intensive changes in deswelling, smaller enthalpy, and entropy changes connected with phase transition and broader temperature interval of the transition than the single network (SN) hydrogels. Above the transition, the DN hydrogels contain significantly more permanently bound water in comparison with SN hydrogels due to interaction of water with the hydrophilic component. Unlike swelling and DSC experiments, a rather abrupt transition was revealed from temperature-dependent NMR spectra. Release study showed that model methylene blue molecules are released from SN and DN hydrogels within different time scale. New thermodynamical model of deswelling behaviour based on the approach of the van't Hoff analysis was developed. The model allows to determine thermodynamic parameters connected with temperature-induced volume transition, such as the standard change of enthalpy and entropy and critical temperatures and characterize the structurally different states of water.

SUBMITTER: Hanykova L

PROVIDER: S-EPMC7692105 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Poly(N,N'-Diethylacrylamide)-Based Thermoresponsive Hydrogels with Double Network Structure.

Hanyková Lenka L Krakovský Ivan I Šestáková Eliška E Šťastná Julie J Labuta Jan J

Polymers 20201027 11

Temperature response of double network (DN) hydrogels composed of thermoresponsive poly(N,N'-diethylacrylamide) (PDEAAm) and hydrophilic polyacrylamide (PAAm) or poly(N,N`-dimethylacrylamide) (PDMAAm) was studied by a combination of swelling measurements, differential scanning calorimetry (DSC) and 1H NMR and UV-Vis spectroscopies. Presence of the second hydrophilic network in DN hydrogels influenced their thermal sensitivity significantly. DN hydrogels show less intensi ...[more]

PMID: 33121186

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Project description:We report the development of thermoresponsive magnetic hydrogels based on poly(N-isopropylacrylamide) encapsulation of Fe3O4 magnetic nanostructures (MNS). In particular, we examined the effects of hydrogels encapsulated with poly-ethylene glycol (PEG) and polyhedral oligomeric silsesquioxane (POSS) surface modified Fe3O4 MNS on magnetic resonance (MR) T2 (transverse spin relaxation) contrast enhancement and associated delivery efficacy of absorbed therapeutic cargo. The microstructural characterization reveal the regular spherical shape and size (?200 nm) of the hydrogels with elevated hydrophilic to hydrophobic transition temperature (?40 °C) characterized by LCST (lower critical solution temperature) due to the presence of encapsulated MNS. The hydrogel-MNS (HGMNS) system encapsulated with PEG functionalized Fe3O4 of 12 nm size (HGMNS-PEG-12) exhibited relaxivity rate (r2) of 173 mM(-1) s(-1) compared to 129 mM(-1) s(-1) obtained for hydrogel-MNS system encapsulated with POSS functionalized Fe3O4 (HGMNS-POSS-12) of the same size. Further studies with HGMNS-PEG-12 with absorbed drug doxorubicin (DOX) reveals approximately two-fold enhance in release during 1 h RF (radio-frequency) field exposure followed by 24 h incubation at 37 °C. Quantitatively, it is 2.1 ?g mg(-1) (DOX/HGMNS) DOX release with RF exposure while only 0.9 ?g mg(-1) release without RF exposure for the same period of incubation. Such enhanced release of therapeutic cargo is attributed to micro-environmental heating in the surroundings of MNS as well as magneto-mechanical vibrations under high frequency RF inside hydrogels. Similarly, RF-induced in vitro localized drug delivery studies with HeLa cell lines for HGMNS-PEG-12 resulted in more than 80% cell death with RF field exposures for 1 h. We therefore believe that magnetic hydrogel system has in vivo theranostic potential given high MR contrast enhancement from encapsulated MNS and RF-induced localized therapeutic delivery in one nanoconstruct.

Dataset Information

Poly(N,N'-Diethylacrylamide)-Based Thermoresponsive Hydrogels with Double Network Structure.

Publications

Poly(<i>N</i>,<i>N'</i>-Diethylacrylamide)-Based Thermoresponsive Hydrogels with Double Network Structure.

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