Ontology highlight
ABSTRACT:
SUBMITTER: Rademacher S
PROVIDER: S-EPMC7692393 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Cells 20201103 11
Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by decreased levels of the survival of motoneuron (SMN) protein. Post-translational mechanisms for regulation of its stability are still elusive. Thus, we aimed to identify regulatory phosphorylation sites that modulate function and stability. Our results show that SMN residues S290 and S292 are phosphorylated, of which SMN pS290 has a detrimental effect on protein stability and nuclear localization. Furthermore, we propose that pho ...[more]