Ontology highlight
ABSTRACT:
SUBMITTER: Dobert JP
PROVIDER: S-EPMC7692748 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Dobert Jan Philipp JP Cabron Anne-Sophie AS Arnold Philipp P Pavlenko Egor E Rose-John Stefan S Zunke Friederike F
Biomedicines 20201030 11
Although extensively investigated, cancer is still one of the most devastating and lethal diseases in the modern world. Among different types, colorectal cancer (CRC) is most prevalent and mortal, making it an important subject of research. The metalloprotease ADAM17 has been implicated in the development of CRC due to its involvement in signaling pathways related to inflammation and cell proliferation. ADAM17 is capable of releasing membrane-bound proteins from the cell surface in a process cal ...[more]