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ABSTRACT:
SUBMITTER: Kampatsikas I
PROVIDER: S-EPMC7693034 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Kampatsikas Ioannis I Pretzler Matthias M Rompel Annette A
Angewandte Chemie (International ed. in English) 20200909 47
Tyrosinases (TYRs) catalyze the hydroxylation of phenols and the oxidation of the resulting o-diphenols to o-quinones, while catechol oxidases (COs) exhibit only the latter activity. Aurone synthase (AUS) is not able to react with classical tyrosinase substrates, such as tyramine and l-tyrosine, while it can hydroxylate its natural substrate isoliquiritigenin. The structural difference of TYRs, COs, and AUS at the heart of their divergent catalytic activities is still a puzzle. Therefore, a libr ...[more]