Ontology highlight
ABSTRACT:
SUBMITTER: Moreno C
PROVIDER: S-EPMC7693138 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Cancers 20201103 11
Succinate dehydrogenase (SDH) complex connects both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC) in the mitochondria. However, <i>SDH</i> mutation or dysfunction-induced succinate accumulation results in multiple cancers and non-cancer diseases. The mechanistic studies show that succinate activates hypoxia response and other signal pathways via binding to 2-oxoglutarate-dependent oxygenases and succinate receptors. Recently, the increasing knowledge of ribonucleic ac ...[more]