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Loss to follow-up in the hepatitis C care cascade: A substantial problem but opportunity for micro-elimination.

ABSTRACT: Since the advent of direct-acting antivirals, elimination of hepatitis C viral (HCV) infections seems within reach. However, studies on the HCV cascade of care show suboptimal progression through each step for all patient groups. Loss to follow-up (LTFU) is a major issue and is a barrier to HCV elimination. This review summarizes the scale of the LTFU problem and proposes a micro-elimination approach. Retrieving LTFU patients and re-engaging them with care again has shown to be feasible in the Netherlands. Micro-elimination through retrieval can contribute to reaching the World Health Organization's viral hepatitis elimination targets by 2030.

SUBMITTER: van Dijk M

PROVIDER: S-EPMC7693174 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Loss to follow-up in the hepatitis C care cascade: A substantial problem but opportunity for micro-elimination.

van Dijk Marleen M Drenth Joost P H JPH

Journal of viral hepatitis 20200922 12

Since the advent of direct-acting antivirals, elimination of hepatitis C viral (HCV) infections seems within reach. However, studies on the HCV cascade of care show suboptimal progression through each step for all patient groups. Loss to follow-up (LTFU) is a major issue and is a barrier to HCV elimination. This review summarizes the scale of the LTFU problem and proposes a micro-elimination approach. Retrieving LTFU patients and re-engaging them with care again has shown to be feasible in the N ...[more]

PMID: 32964615

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