Ontology highlight
ABSTRACT:
SUBMITTER: Deragon MA
PROVIDER: S-EPMC7693268 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Deragon Matthew A MA McCaig William D WD Patel Payal S PS Haluska Robert J RJ Hodges Alexa L AL Sosunov Sergey A SA Murphy Michael P MP Ten Vadim S VS LaRocca Timothy J TJ
Cell death discovery 20201126 1
We have previously identified a shift from TNF-α-induced apoptosis to necroptosis that occurs under hyperglycemic conditions. This shift involves the downregulation or silencing of caspases and concurrent upregulation of necroptotic proteins leading to activation of the necrosome. In addition, under hyperglycemic conditions in vivo, this shift in cell death mechanisms exacerbates neonatal hypoxia-ischemia (HI) brain injury. Here, we identify two major factors that drive the hyperglycemic shift t ...[more]