Ontology highlight
ABSTRACT:
SUBMITTER: Kikuoka R
PROVIDER: S-EPMC7693322 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Kikuoka Ryo R Miyazaki Ikuko I Kubota Natsuki N Maeda Megumi M Kagawa Daiki D Moriyama Masaaki M Sato Asuka A Murakami Shinki S Kitamura Yoshihisa Y Sendo Toshiaki T Asanuma Masato M
Scientific reports 20201126 1
Mirtazapine, a noradrenergic and specific serotonergic antidepressant (NaSSA), is known to activate serotonin (5-HT) 1A receptor. Our recent study demonstrated that stimulation of astrocytic 5-HT1A receptors promoted astrocyte proliferation and upregulated antioxidative property in astrocytes to protect dopaminergic neurons against oxidative stress. Here, we evaluated the neuroprotective effects of mirtazapine against dopaminergic neurodegeneration in models of Parkinson's disease (PD). Mirtazap ...[more]