Multiple Feature Selection Strategies Identified Novel Cardiac Gene Expression Signature for Heart Failure.

ABSTRACT: Heart failure (HF) is a serious condition in which the support of blood pumped by the heart is insufficient to meet the demands of body at a normal cardiac filling pressure. Approximately 26 million patients worldwide are suffering from heart failure and about 17-45% of patients with heart failure die within 1-year, and the majority die within 5-years admitted to a hospital. The molecular mechanisms underlying the progression of heart failure have been poorly studied. We compared the gene expression profiles between patients with heart failure (n = 177) and without heart failure (n = 136) using multiple feature selection strategies and identified 38 HF signature genes. The support vector machine (SVM) classifier based on these 38 genes evaluated with leave-one-out cross valid

SUBMITTER: Li D 

PROVIDER: S-EPMC7693561 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature