Ontology highlight
ABSTRACT:
SUBMITTER: V Volozhantsev N
PROVIDER: S-EPMC7693772 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
V Volozhantsev Nikolay N M Shpirt Anna A I Borzilov Alexander A V Komisarova Ekaterina E M Krasilnikova Valentina V S Shashkov Alexander A V Verevkin Vladimir V A Knirel Yuriy Y
Antibiotics (Basel, Switzerland) 20201025 11
Bacteriophages and phage enzymes are considered as possible alternatives to antibiotics in the treatment of infections caused by antibiotic-resistant bacteria. Due to the ability to cleave the capsular polysaccharides (CPS), one of the main virulence factors of <i>Klebsiella pneumoniae</i>, phage depolymerases, has potential in the treatment of <i>K. pneumoniae</i> infections. Here, we characterized in vivo two novel phage-encoded polysaccharide depolymerases as therapeutics against clinical iso ...[more]