Cardiac and Vascular ?1-Adrenoceptors in Congestive Heart Failure: A Systematic Review.

ABSTRACT: As heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates ?- and ?-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of ?-ARs. However, information on the role of ?-AR is limited. We have performed a systematic literature review examining the role of both cardiac and vascular ?1-ARs in HF using 5 databases for our search. All three ?1-AR subtypes (?1A, ?1B and ?1D) are expressed in human and animal hearts and blood vessels in a tissue-dependent manner. We summarize the changes observed in HF regarding the density, signaling and responses of ?1-ARs. Conflicting findings arise from different studies concerning the influence that HF has on ?1-AR expression and function; in contrast to ?-ARs there is no consistent evidence for down-regulation or desensitization of cardiac or vascular ?1-ARs. Whether ?1-ARs are a therapeutic target in HF remains a matter of debate.

SUBMITTER: Kayk?-Mutlu G 

PROVIDER: S-EPMC7694190 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature