Chromosomal Instability in Tumor Initiation and Development.
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ABSTRACT:
SUBMITTER: Bach DH
PROVIDER: S-EPMC7694409 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Chromosomal Instability in Tumor Initiation and Development.
Bach Duc-Hiep DH Zhang Wei W Sood Anil K AK
Cancer research 20190726 16
Chromosomal instability (CIN) is one of the major forms of genomic instability in various human cancers and is recognized as a common hallmark of tumorigenesis and heterogeneity. However, some malignant tumors show a paucity of chromosomal alterations, suggesting that tumor progression and evolution can occur in the absence of CIN. It is unclear whether CIN is stable between precursor lesions, primary tumor, and metastases or if it evolves during these steps. In this review, we describe the infl ...[more]
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