Ontology highlight
ABSTRACT:
SUBMITTER: Harroud A
PROVIDER: S-EPMC7694579 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Harroud Adil A Richards J Brent JB Baranzini Sergio E SE
Neurology(R) neuroimmunology & neuroinflammation 20201119 1
<h4>Objective</h4>To examine whether lifelong genetically increased serum urate levels, a potent antioxidant, contribute to MS susceptibility using Mendelian randomization (MR).<h4>Methods</h4>This 2-sample MR study included 25 independent genetic variants strongly associated with serum urate levels in a genome-wide association study meta-analysis of 140,949 individuals. Effects on the risk of MS were assessed with summary statistics from 3 large-scale MS genetic data sets totaling 61,667 MS cas ...[more]