Intragastric pH of foals admitted to the intensive care unit.

ABSTRACT: Background: Intragastric pH profiles of neonatal foals admitted to the intensive care unit (ICU) remain poorly characterized.

Hypothesis/objectives: To determine intragastric pH profiles and clinical parameters associated with intragastric pH in foals admitted to the ICU.

Animals: Forty-two neonatal foals admitted to the ICU and requiring placement of an indwelling nasogastric tube for nutritional management were included.

Methods: Intragastric pH was measured for 24?hours from the time of admission. Mean pH, % time pH <4, and % time pH >4 were determined for each foal. History, clinical findings, and clinicopathological data recorded at the time of presentation were collected.

Results: The mean pH of included foals was 5.5?±?1.8. The median % time pH <4 was 6.3% (range: 0-99). A history of placentitis was associated with greater mean pH (median 5.3 (range: 0.9-7.8) versus median 7.2 (5.9-11.3); P = .002) and less % time pH <4 (median 13 (0-99.6) versus median 0.1 (0-7.2); P = .01). Foals with diarrhea had a greater % time pH <4 (median 4.6% (0-99) versus median 28.8% (1.4-57.48); P = .02). Foals with a pH >4 for >50% recording time had a lower PaO₂ (mean difference 25.0?mm Hg; 95% confidence interval [CI], 14.4-35.6; P = .03) and higher PaCO₂ (mean difference 14.9?mm Hg; 95% CI, 4.7-25.2; P = .02). Surviving foals had a lower mean median hourly pH (P = .02).

Conclusions and clinical importance: Intragastric pH profiles were unpredictable and mostly >4 for >80% of the recording time. This study does not support the indiscriminate administration of acid suppressive treatment.

SUBMITTER: Wise JC 

PROVIDER: S-EPMC7694801 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature