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Extracellular matrix-based biomaterials as adipose-derived stem cell delivery vehicles in wound healing: a comparative study between a collagen scaffold and two xenografts.


ABSTRACT: BACKGROUND:Stem cell therapies represent a promising tool in regenerative medicine. Considering the drawbacks of direct stem cell injections (e.g. poor cell localisation), extracellular matrix-based biomaterials (e.g. scaffolds and tissue grafts), due to their compositional biofunctionality and cytocompatibility, are under investigation as potential stem cell carriers. METHODS:The present study assessed the potential of three commercially available extracellular matrix-based biomaterials [a collagen/glycosaminoglycan scaffold (Integra™ Matrix Wound Dressing), a decellularised porcine peritoneum (XenoMEM™) and a porcine urinary bladder (MatriStem™)] as human adipose-derived stem cell delivery vehicles. RESULTS:Both tissue grafts induced significantly (p?

SUBMITTER: Capella-Monsonis H 

PROVIDER: S-EPMC7694925 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Extracellular matrix-based biomaterials as adipose-derived stem cell delivery vehicles in wound healing: a comparative study between a collagen scaffold and two xenografts.

Capella-Monsonís Héctor H   De Pieri Andrea A   Peixoto Rita R   Korntner Stefanie S   Zeugolis Dimitrios I DI  

Stem cell research & therapy 20201127 1


<h4>Background</h4>Stem cell therapies represent a promising tool in regenerative medicine. Considering the drawbacks of direct stem cell injections (e.g. poor cell localisation), extracellular matrix-based biomaterials (e.g. scaffolds and tissue grafts), due to their compositional biofunctionality and cytocompatibility, are under investigation as potential stem cell carriers.<h4>Methods</h4>The present study assessed the potential of three commercially available extracellular matrix-based bioma  ...[more]

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