Ontology highlight
ABSTRACT:
SUBMITTER: Gao T
PROVIDER: S-EPMC7695407 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Gao Tianyi T Liu Xiangxiang X He Bangshun B Pan Yuqin Y Wang Shukui S
Aging 20201105 21
Cancer stem cells (CSCs) are believed to be the driving force behind the tumor growth. We performed this study to further explore the role of IGF2 epigenetic on CRC stem cells pluripotency which showed that IGF2 LOI CRC cells usually had a higher CD133 expression and sphere forming efficiency than MOI cells. IGF2 LOI CSCs were also found to have a higher level of autophagy than MOI CSCs. Moreover, IGF2/IR-A signal was determined to play a more important role in CSCs formation than IGF2/IGF1R. At ...[more]