Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Franzmeier N
PROVIDER: S-EPMC7695466 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease.
Franzmeier Nicolai N Dewenter Anna A Frontzkowski Lukas L Dichgans Martin M Rubinski Anna A Neitzel Julia J Smith Ruben R Strandberg Olof O Ossenkoppele Rik R Buerger Katharina K Duering Marco M Hansson Oskar O Ewers Michael M
Science advances 20201127 48
In Alzheimer's disease (AD), the Braak staging scheme suggests a stereotypical tau spreading pattern that does, however, not capture interindividual variability in tau deposition. This complicates the prediction of tau spreading, which may become critical for defining individualized tau-PET readouts in clinical trials. Since tau is assumed to spread throughout connected regions, we used functional connectivity to improve tau spreading predictions over Braak staging methods. We included two sampl ...[more]
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