Ontology highlight
ABSTRACT:
SUBMITTER: Avet C
PROVIDER: S-EPMC7695697 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Avet Charlotte C Sturino Claudio C Grastilleur Sébastien S Gouill Christian Le CL Semache Meriem M Gross Florence F Gendron Louis L Bennani Youssef Y Mancini Joseph A JA Sayegh Camil E CE Bouvier Michel M
Communications biology 20201127 1
Protease-activated receptor-2 (PAR2) is involved in inflammatory responses and pain, therefore representing a promising therapeutic target for the treatment of immune-mediated inflammatory diseases. However, as for other GPCRs, PAR2 can activate multiple signaling pathways and those involved in inflammatory responses remain poorly defined. Here, we describe a new selective and potent PAR2 inhibitor (I-287) that shows functional selectivity by acting as a negative allosteric regulator on Gα<sub>q ...[more]