Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC7695701 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Wang Zhiming Z Rahkola Jeremy J Redzic Jasmina S JS Chi Ying-Chih YC Tran Norman N Holyoak Todd T Zheng Hongjin H Janoff Edward E Eisenmesser Elan E
Nature communications 20201127 1
Opportunistic pathogens such as Streptococcus pneumoniae secrete a giant metalloprotease virulence factor responsible for cleaving host IgA1, yet the molecular mechanism has remained unknown since their discovery nearly 30 years ago despite the potential for developing vaccines that target these enzymes to block infection. Here we show through a series of cryo-electron microscopy single particle reconstructions how the Streptococcus pneumoniae IgA1 protease facilitates IgA1 substrate recognition ...[more]