Ontology highlight
ABSTRACT:
SUBMITTER: Olan I
PROVIDER: S-EPMC7695716 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Olan Ioana I Parry Aled J AJ Schoenfelder Stefan S Narita Masako M Ito Yoko Y Chan Adelyne S L ASL Slater Guy St C GSC Bihary Dóra D Bando Masashige M Shirahige Katsuhiko K Kimura Hiroshi H Samarajiwa Shamith A SA Fraser Peter P Narita Masashi M
Nature communications 20201127 1
Senescence is a state of stable proliferative arrest, generally accompanied by the senescence-associated secretory phenotype, which modulates tissue homeostasis. Enhancer-promoter interactions, facilitated by chromatin loops, play a key role in gene regulation but their relevance in senescence remains elusive. Here, we use Hi-C to show that oncogenic RAS-induced senescence in human diploid fibroblasts is accompanied by extensive enhancer-promoter rewiring, which is closely connected with dynamic ...[more]