A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer.
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ABSTRACT:
SUBMITTER: Gormley M
PROVIDER: S-EPMC7695733 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer.
Gormley Mark M Dudding Tom T Sanderson Eleanor E Martin Richard M RM Thomas Steven S Tyrrell Jessica J Ness Andrew R AR Brennan Paul P Munafò Marcus M Pring Miranda M Boccia Stefania S Olshan Andrew F AF Diergaarde Brenda B Hung Rayjean J RJ Liu Geoffrey G Davey Smith George G Richmond Rebecca C RC
Nature communications 20201127 1
The independent effects of smoking and alcohol in head and neck cancer are not clear, given the strong association between these risk factors. Their apparent synergistic effect reported in previous observational studies may also underestimate independent effects. Here we report multivariable Mendelian randomization performed in a two-sample approach using summary data on 6,034 oral/oropharyngeal cases and 6,585 controls from a recent genome-wide association study. Our results demonstrate strong ...[more]
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