Ontology highlight
ABSTRACT:
SUBMITTER: Kachuri L
PROVIDER: S-EPMC7695829 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Kachuri Linda L Graff Rebecca E RE Smith-Byrne Karl K Meyers Travis J TJ Rashkin Sara R SR Ziv Elad E Witte John S JS Johansson Mattias M
Nature communications 20201127 1
Cancer risk is determined by a complex interplay of environmental and heritable factors. Polygenic risk scores (PRS) provide a personalized genetic susceptibility profile that may be leveraged for disease prediction. Using data from the UK Biobank (413,753 individuals; 22,755 incident cancer cases), we quantify the added predictive value of integrating cancer-specific PRS with family history and modifiable risk factors for 16 cancers. We show that incorporating PRS measurably improves prediction ...[more]